What is Nuceiva?
You may have heard of the new kid on the block — Nuceiva, also known as “Newtox” or Jeuveau in the US, is rapidly gaining popularity. Nuceiva is the first neurotoxin to be approved for wrinkle treatments by Health Canada in over 20 years. This product was designed exclusively for cosmetic purposes, particularly to reduce the appearance of lines and wrinkles on the forehead and between the eyebrows. It was developed as a direct competitor to Botox with its notable “next-generation” purified botulinum toxin formula.
Like other neuromodulators, Nuceiva blocks the nerves that prompt muscles to contract, resulting in muscle relaxation and reduced lines and wrinkles, yielding smoother, more youthful skin.
What’s the difference?
Not much! All of the approved neuromodulators in Canada are brands of botulinum toxin type A (think same ingredients, different recipe!). While Botox (onabotulinum toxin-A) is made by Allergan and manufactured in Ireland, Nuceiva (prabotulinum toxin-A) is made by Evolus in South Korea. Like Botox/Dysport, a Nuceiva treatment takes anywhere from 10-15 minutes with minimal to no downtime.
Nuceiva boasts a faster onset of action with results visible in as little as 2 days and potentially longer-lasting effects of up to five months. Compared to Botox and Dysport, this “next-generation” neurotoxin is said to be a more pure and precise formulation. This purity provides an advantage over other neurotoxins in that it is less likely to cause antibody formation, which over time can reduce the effectiveness of treatment. It is created with the same molecular weight as Botox (900kDa) and with greater precision, which allows for more movement than Botox, resulting in more natural-looking results.
A lot has changed since Botox entered the market over 30 years ago, and Nuceiva has been warmly welcomed by injectors and patients, marking a significant advancement in wrinkle treatment options.
Choosing between Botox, Dysport: and Neceiva
Choosing between Botox, Dysport, and Nuceiva involves several decision factors. Each product has unique characteristics that might make one more suitable for a particular patient or treatment goal. Here are the key factors to consider:
1. Onset of Action
- Botox: Typically, patients see results within 3-5 days after treatment.
- Dysport: Often has a quicker onset, with results visible in 2-3 days.
- Nuceiva: Known for its rapid onset, with effects sometimes visible within 2 days.
2. Duration of Effects
- Botox: Effects usually last around 3-4 months.
- Dysport: Similar duration to Botox, often lasting 3-4 months.
- Nuceiva: Reports suggest it may last up to 5 months, offering potentially longer-lasting results.
3. Spread and Diffusion
- Botox: Tends to stay localized to the injection site, making it suitable for precise treatments.
- Dysport: Has a tendency to spread more, which can be advantageous for treating larger areas but requires more skill to avoid unwanted diffusion.
- Nuceiva: Offers precise targeting similar to Botox but with potentially greater purity and precision.
4. Purity and Formulation
- Botox: Contains onabotulinumtoxinA with accessory proteins that can sometimes cause antibody formation, reducing effectiveness over time.
- Dysport: Contains abobotulinumtoxinA and may have a different protein structure, which can influence its spread.
- Nuceiva: Contains prabotulinumtoxinA-xvfs and is marketed as having a highly purified formulation, potentially reducing the risk of antibody formation and improving safety.
5. Cost
- Botox: Generally priced higher due to its brand recognition and established track record.
- Dysport: Can be slightly cheaper per unit, but requires more units per treatment area, which can affect overall cost.
- Nuceiva: Pricing can be competitive, and its longer duration might offer better value for some patients.
6. Patient Experience and Preferences
- Botox: Long track record with high patient satisfaction and familiarity among both patients and practitioners.
- Dysport: Preferred by some for its faster onset and broader spread, useful for treating larger areas.
- Nuceiva: Newer to the market but gaining popularity due to its quick results and perceived purity.
7. Potential for Antibody Formation
- Botox: Antibody formation is rare but possible with long-term use.
- Dysport: Slightly different protein structure might reduce the risk of antibody formation for some individuals.
- Nuceiva: Claimed to have a lower risk of antibody formation due to its high purity.
8. Injection Technique
- Botox: Requires precise dosing and technique, often well-understood due to its long history.
- Dysport: Requires more units and may spread more, demanding careful administration.
- Nuceiva: Newer product, but practitioners report it requires precision similar to Botox with potential advantages in ease of use.
Ultimately, the choice between Botox, Dysport, and Nuceiva will depend on individual patient needs, treatment goals, and preferences. Consulting with an experienced provider can help determine the most suitable option based on these factors.
Click here to learn more about Botox and Dysport.
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